Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases

Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases

Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome. These findings suggest that H3K9 methyltransferases play an important role in maintaining genome organization in more transcriptionally inactive com...

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Main Authors: Kei Fukuda, Chikako Shimura, Hisashi Miura, Akie Tanigawa, Takehiro Suzuki, Naoshi Dohmae, Ichiro Hiratani, Yoichi Shinkai
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02089-y
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spelling doaj-e89beff64c854c29ab9276b1ff88ac502021-05-16T11:21:20ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111310.1038/s42003-021-02089-yRegulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferasesKei Fukuda0Chikako Shimura1Hisashi Miura2Akie Tanigawa3Takehiro Suzuki4Naoshi Dohmae5Ichiro Hiratani6Yoichi Shinkai7Cellular Memory Laboratory, RIKEN Cluster for Pioneering ResearchCellular Memory Laboratory, RIKEN Cluster for Pioneering ResearchLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics ResearchBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource ScienceBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource ScienceLaboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics ResearchCellular Memory Laboratory, RIKEN Cluster for Pioneering ResearchKei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome. These findings suggest that H3K9 methyltransferases play an important role in maintaining genome organization in more transcriptionally inactive compartments.https://doi.org/10.1038/s42003-021-02089-y
collection DOAJ
language English
format Article
sources DOAJ
author Kei Fukuda
Chikako Shimura
Hisashi Miura
Akie Tanigawa
Takehiro Suzuki
Naoshi Dohmae
Ichiro Hiratani
Yoichi Shinkai
spellingShingle Kei Fukuda
Chikako Shimura
Hisashi Miura
Akie Tanigawa
Takehiro Suzuki
Naoshi Dohmae
Ichiro Hiratani
Yoichi Shinkai
Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
Communications Biology
author_facet Kei Fukuda
Chikako Shimura
Hisashi Miura
Akie Tanigawa
Takehiro Suzuki
Naoshi Dohmae
Ichiro Hiratani
Yoichi Shinkai
author_sort Kei Fukuda
title Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
title_short Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
title_full Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
title_fullStr Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
title_full_unstemmed Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
title_sort regulation of mammalian 3d genome organization and histone h3k9 dimethylation by h3k9 methyltransferases
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome. These findings suggest that H3K9 methyltransferases play an important role in maintaining genome organization in more transcriptionally inactive compartments.
url https://doi.org/10.1038/s42003-021-02089-y
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