Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

Pregnane X receptor (PXR) is an important nuclear receptor xenosensor that regulates the expression of metabolic enzymes and transporters involved in the metabolism of xenobiotics and endobiotics. In this study, ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight...

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Bibliographic Details
Main Authors: Joo-Youn Cho, Dong Wook Kang, Xiaochao Ma, Sung-Hoon Ahn, Kristopher W. Krausz, Hans Luecke, Jeffrey R. Idle, Frank J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Journal of Lipid Research
Subjects:
pregnane X receptor
pregnenolone 16α-carbonitrile
carboxyethyl hydroxychroman
metabolomics
γ-CEHC glucoside
sterol carrier protein 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308452

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http://www.sciencedirect.com/science/article/pii/S0022227520308452

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