Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

Neurofibrillary degeneration in transgenic models of tauopathies has been observed to be enhanced when these models are crossed with transgenic models developing an Aβ pathology. The mechanisms leading to this enhanced tau pathology are not well understood. We have performed a detailed analysis of t...

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Bibliographic Details
Main Authors: Céline Héraud, Doris Goufak, Kunie Ando, Karelle Leroy, Valérie Suain, Zehra Yilmaz, Robert De Decker, Michèle Authelet, Vincent Laporte, Jean-Noël Octave, Jean-Pierre Brion
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Tau
APP
PS1
Neurofibrillary tangles
Aβ
Alzheimer
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002568

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http://www.sciencedirect.com/science/article/pii/S0969996113002568

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