FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons

FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons

A missense mutation in the fibroblast growth factor 14 (FGF14) gene underlies SCA27, an autosomal dominant spinocerebellar ataxia in humans. Mice with a targeted disruption of the Fgf14 locus (Fgf14−/−) develop ataxia resembling human SCA27. We tested the hypothesis that loss of FGF14 affects the fi...

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Bibliographic Details
Main Authors: Vikram G. Shakkottai, Maolei Xiao, Lin Xu, Michael Wong, Jeanne M. Nerbonne, David M. Ornitz, Kelvin A. Yamada
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neurobiology of Disease
Subjects:
Spinocerebellar ataxia
Intracellular fibroblast growth factor 14 (iFGF14)
Purkinje neurons
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SCA27
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002271

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http://www.sciencedirect.com/science/article/pii/S0969996108002271

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