Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation

Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation

Zinc finger nucleases (ZFN) can facilitate targeted gene addition to the genome while minimizing the risks of insertional mutagenesis. Here, we used a previously characterized ZFN pair targeting the chemokine (C-C motif) receptor 5 (CCR5) locus to introduce, as a proof of concept, the enhanced green...

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Bibliographic Details
Main Authors: Basma F Benabdallah, Arnaud Duval, Joel Rousseau, Pierre Chapdelaine, Michael C Holmes, Eli Haddad, Jacques P Tremblay, Christian M Beauséjour
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
dystrophin
gene addition
gene therapy
myoblast
zinc finger nuclease
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301238

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http://www.sciencedirect.com/science/article/pii/S2162253116301238

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