Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation. In the most well-understood "canonical" Wnt signaling pathway, Wnt binding to Frizzled receptors induces beta-caten...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-04-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1420652?pdf=render |