In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.

Bibliographic Details
Main Authors: Xiangbo Ruan, Ping Li, Yi Chen, Yu Shi, Mehdi Pirooznia, Fayaz Seifuddin, Hiroshi Suemizu, Yasuyuki Ohnishi, Nao Yoneda, Megumi Nishiwaki, James Shepherdson, Abhilash Suresh, Komudi Singh, Yonghe Ma, Cheng-fei Jiang, Haiming Cao
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13688-z

Internet

https://doi.org/10.1038/s41467-019-13688-z

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