Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.

Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a large repertoire of ~2,000 genes. T. brucei express...

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Bibliographic Details
Main Authors: Siddharth Jayaraman, Claire Harris, Edith Paxton, Anne-Marie Donachie, Heli Vaikkinen, Richard McCulloch, James P J Hall, John Kenny, Luca Lenzi, Christiane Hertz-Fowler, Christina Cobbold, Richard Reeve, Tom Michoel, Liam J Morrison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6464242?pdf=render

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http://europepmc.org/articles/PMC6464242?pdf=render

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