Nanobody-enabled monitoring of kappa opioid receptor states
Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states with KOR and other GPCRs.
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-14889-7 |