The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.

by Bryan L Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen
Published 2013-01-01

Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor.

by Bryan L Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen
Published 2018-01-01

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT2 receptor family

by Adam Pigott, Stewart Frescas, John D. McCorvy, Xi-Ping Huang, Bryan L. Roth, David E. Nichols
Published 2012-10-01

Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor

by David Y. W. Lee, Lee-Yuan Liu-Chen, Bryan L. Roth, Niels H. Jensen, Wei Xu, Zhong-Ze Ma
Published 2008-09-01

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.

by John D Chan, John D McCorvy, Sreemoyee Acharya, Malcolm E Johns, Timothy A Day, Bryan L Roth, Jonathan S Marchant
Published 2016-05-01

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

by Ramona M. Rodriguiz, Vineet Nadkarni, Christopher R. Means, Vladimir M. Pogorelov, Yi-Ting Chiu, Bryan L. Roth, William C. Wetsel
Published 2021-09-01

Securinine, a myeloid differentiation agent with therapeutic potential for AML.

by Kalpana Gupta, Amitabha Chakrabarti, Sonia Rana, Ritu Ramdeo, Bryan L Roth, Munna L Agarwal, William Tse, Mukesh K Agarwal, David N Wald
Published 2011-01-01

DREADDs in Drosophila: A Pharmacogenetic Approach for Controlling Behavior, Neuronal Signaling, and Physiology in the Fly

by Jaime Becnel, Oralee Johnson, Zana R. Majeed, Vi Tran, Bangning Yu, Bryan L. Roth, Robin L. Cooper, Edmund K. Kerut, Charles D. Nichols
Published 2013-09-01

Far away from the lamppost.

by Tudor I Oprea, Lily Jan, Gary L Johnson, Bryan L Roth, Avi Ma'ayan, Stephan Schürer, Brian K Shoichet, Larry A Sklar, Michael T McManus
Published 2018-12-01

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

by George A Lemieux, Michael J Keiser, Maria F Sassano, Christian Laggner, Fahima Mayer, Roland J Bainton, Zena Werb, Bryan L Roth, Brian K Shoichet, Kaveh Ashrafi
Published 2013-11-01

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

by Michael V. Morabito, Atheir I. Abbas, Jennifer L. Hood, Robert A. Kesterson, Michelle M. Jacobs, David S. Kump, David L. Hachey, Bryan L. Roth, Ronald B. Emeson
Published 2010-08-01

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

by John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Published 2017-12-01

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

by Thomas A Munro, Xi-Ping Huang, Carmela Inglese, Maria Grazia Perrone, Ashlee Van't Veer, F Ivy Carroll, Cécile Béguin, William A Carlezon, Nicola A Colabufo, Bruce M Cohen, Bryan L Roth
Published 2013-01-01

Nanobody-enabled monitoring of kappa opioid receptor states

by Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
Published 2020-03-01

Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders.

by Hu Zhu, Daniel J Urban, Jared Blashka, Matthew T McPheeters, Wesley K Kroeze, Piotr Mieczkowski, James C Overholser, George J Jurjus, Lesa Dieter, Gouri J Mahajan, Grazyna Rajkowska, Zefeng Wang, Patrick F Sullivan, Craig A Stockmeier, Bryan L Roth
Published 2012-01-01

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

by Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Published 2021-02-01

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.

by Martilias S Farrell, John D McCorvy, Xi-Ping Huang, Daniel J Urban, Kate L White, Patrick M Giguere, Allison K Doak, Alison I Bernstein, Kristen A Stout, Su Mi Park, Ramona M Rodriguiz, Bradley W Gray, William S Hyatt, Andrew P Norwood, Kevin A Webster, Brenda M Gannon, Gary W Miller, Joseph H Porter, Brian K Shoichet, William E Fantegrossi, William C Wetsel, Bryan L Roth
Published 2016-01-01

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

by Robert W. Malone, Robert W. Malone, Philip Tisdall, Philip Fremont-Smith, Yongfeng Liu, Xi-Ping Huang, Kris M. White, Kris M. White, Lisa Miorin, Lisa Miorin, Elena Moreno, Elena Moreno, Assaf Alon, Elise Delaforge, Christopher D. Hennecker, Guanyu Wang, Joshua Pottel, Robert V. Blair, Robert V. Blair, Chad J. Roy, Chad J. Roy, Nora Smith, Julie M. Hall, Kevin M Tomera, Gideon Shapiro, Anthony Mittermaier, Andrew C. Kruse, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Bryan L. Roth, Jill Glasspool-Malone, Darrell O. Ricke
Published 2021-03-01

Donated chemical probes for open science

by Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Published 2018-04-01