Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6

by Morgan Thurman, Jacob van Doorn, Barbara Danzer, Thomas R Webb, Stefan Stamm
Published 2017-09-01

Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel.

by Ravi S Kasinathan, Lalit Kumar Sharma, Charles Cunningham, Thomas R Webb, Robert M Greenberg
Published 2014-10-01

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

by George B. Kyei, Shanshan Meng, Rashmi Ramani, Austin Niu, Chandraiah Lagisetti, Thomas R. Webb, Lee Ratner
Published 2018-11-01

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications.

by Yihui Shi, Walter Bray, Alexander J Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R Scott Lokey, Thomas R Webb
Published 2020-01-01

Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease.

by Rebecca M DuBois, P Jake Slavish, Brandi M Baughman, Mi-Kyung Yun, Ju Bao, Richard J Webby, Thomas R Webb, Stephen W White
Published 2012-01-01

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

by John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Published 2017-12-01

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

by Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter
Published 2017-01-01