Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Corydaline is a bioactive alkaloid with various antiacetylcholinesterase, antiallergic, and antinociceptive activities found in the medicinal herb Corydalis Tubers. The inhibitory potential of corydaline on the activities of seven major human cytochrome P450 and four UDP-glucuronosyltransferase enzy...

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Bibliographic Details
Main Authors: Hyun Joo Shim, Miwon Son, Hye Suk Lee, Hyeri Lee, Sae Rom Im, Hye Young Ji, Kwang Hyeon Liu
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
corydaline
cytochrome P450 inhibition
UDP-glucuronosyltransferase inhibition
human liver microsomes
drug-drug interaction
Online Access:http://www.mdpi.com/1420-3049/16/8/6591/

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http://www.mdpi.com/1420-3049/16/8/6591/

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