Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis

Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis

Background & Aims: Liver lobules are typically subdivided into 3 metabolic zones: zones 1, 2, and 3. However, the contribution of zonal differences in hepatocytes to liver regeneration, as well as to carcinogenic susceptibility, remains unclear. Methods: We developed a new method for sustain...

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Bibliographic Details
Main Authors: Shigeyuki Kurosaki, Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Yuki Matsushita, Tomoharu Yamada, Koji Uchino, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Hiroto Kinoshita, Yasuo Tanaka, Takuma Nakatsuka, Yoshihiro Hirata, Keisuke Tateishi, Kazuhiko Koike
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:JHEP Reports
Subjects:
Hepatocellular carcinoma
Liver regeneration
Metabolic dysfunction-associated fatty liver disease
Wnt/β-catenin signal
Metabolic zonation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000914

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http://www.sciencedirect.com/science/article/pii/S2589555921000914

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