MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single experiment. Despite the importance of MAVE data for basic and clinical research, there is no standard resource for their discover...

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Bibliographic Details
Main Authors: Daniel Esposito, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P. Roth, Douglas M. Fowler, Alan F. Rubin
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Subjects:
Deep mutational scanning
Massively parallel reporter assays
Large-scale mutagenesis
MAVE
Multiplexed assay of variant effect
Genome interpretation
Online Access:http://link.springer.com/article/10.1186/s13059-019-1845-6

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http://link.springer.com/article/10.1186/s13059-019-1845-6

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