Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Abstract Background α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synucleinopathies, such as Parkinson’s disease (PD) or dement...

Full description

Bibliographic Details
Main Authors: Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens, Inga Zerr
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Translational Neurodegeneration
Subjects:
RT-QuIC
α-Synucleinopathies
Protein misfolding
Protein strains
Online Access:https://doi.org/10.1186/s40035-019-0181-9

Internet

https://doi.org/10.1186/s40035-019-0181-9

Similar Items