Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Chronic microglial activation has been linked to the progressive degeneration of the nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis. The exact etiology of PD remains poorly understood. Although both oxidative stress and neuroinflammation are identified as...

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Bibliographic Details
Main Authors: Richard Gordon, Neeraj Singh, Vivek Lawana, Anamitra Ghosh, Dilshan S. Harischandra, Huajun Jin, Colleen Hogan, Souvarish Sarkar, Dharmin Rokad, Nikhil Panicker, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Microglial activation
PKCδ
NFκB
Neuroinflammation
α-Synuclein
PKC delta
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300900

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http://www.sciencedirect.com/science/article/pii/S0969996116300900

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