Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain

Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain

Abstract Background Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. The same neurons were shown to produce the endogenous ligand aldosterone...

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Bibliographic Details
Main Authors: Mohammed Shaqura, Li Li, Doaa M. Mohamed, Xiongjuan Li, Sascha Treskatsch, Constanze Buhrmann, Mehdi Shakibaei, Antje Beyer, Shaaban A. Mousa, Michael Schäfer
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Aldosterone synthase
Pain signaling molecules
Sensory neurons
Online Access:http://link.springer.com/article/10.1186/s12974-020-01864-8

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http://link.springer.com/article/10.1186/s12974-020-01864-8

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