HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

Previously, we engineered oncolytic herpes simplex viruses (o-HSVs) retargeted to the HER2 (epidermal growth factor receptor 2) tumor cell specific receptor by the insertion of a single chain antibody (scFv) to HER2 in gD, gH, or gB. Here, the insertion of scFvs to three additional cancer targets&am...

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Bibliographic Details
Main Authors: Laura Menotti, Elisa Avitabile, Valentina Gatta, Paolo Malatesta, Biljana Petrovic, Gabriella Campadelli-Fiume
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Viruses
Subjects:
retargeting
oncolytic herpesvirus
PSMA
EGFR
EGFRvIII
mIL12
Gaussia Luciferase
HER2
Online Access:http://www.mdpi.com/1999-4915/10/7/352

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http://www.mdpi.com/1999-4915/10/7/352

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