TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.

After infection with Borrelia species, the risk for developing Lyme disease varies significantly between individuals. Recognition of Borrelia by the immune system is mediated by pattern recognition receptors (PRRs), such as TLRs. While TLR2 is the main recognition receptor for Borrelia spp., little...

Full description

Bibliographic Details
Main Authors: Marije Oosting, Hadewych Ter Hofstede, Patrick Sturm, Gosse J Adema, Bart-Jan Kullberg, Jos W M van der Meer, Mihai G Netea, Leo A B Joosten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187844?pdf=render