Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour durin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11741-5 |