Differential regulation of OCT4 targets facilitates reacquisition of pluripotency

Differential regulation of OCT4 targets facilitates reacquisition of pluripotency

Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour durin...

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Main Authors: Sudhir Thakurela, Camille Sindhu, Evgeny Yurkovsky, Christina Riemenschneider, Zachary D. Smith, Iftach Nachman, Alexander Meissner
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11741-5
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spelling doaj-ecff860b9f7e4f0fa81f283c7a870aea2021-05-11T12:41:39ZengNature Publishing GroupNature Communications2041-17232019-09-0110111110.1038/s41467-019-11741-5Differential regulation of OCT4 targets facilitates reacquisition of pluripotencySudhir Thakurela0Camille Sindhu1Evgeny Yurkovsky2Christina Riemenschneider3Zachary D. Smith4Iftach Nachman5Alexander Meissner6Department of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Biochemistry and Molecular Biology, Tel Aviv UniversityDepartment of Genome Regulation, Max Planck Institute for Molecular GeneticsDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Biochemistry and Molecular Biology, Tel Aviv UniversityDepartment of Stem Cell and Regenerative Biology, Harvard UniversityBarriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour during differentiation.https://doi.org/10.1038/s41467-019-11741-5
collection DOAJ
language English
format Article
sources DOAJ
author Sudhir Thakurela
Camille Sindhu
Evgeny Yurkovsky
Christina Riemenschneider
Zachary D. Smith
Iftach Nachman
Alexander Meissner
spellingShingle Sudhir Thakurela
Camille Sindhu
Evgeny Yurkovsky
Christina Riemenschneider
Zachary D. Smith
Iftach Nachman
Alexander Meissner
Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Nature Communications
author_facet Sudhir Thakurela
Camille Sindhu
Evgeny Yurkovsky
Christina Riemenschneider
Zachary D. Smith
Iftach Nachman
Alexander Meissner
author_sort Sudhir Thakurela
title Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_short Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_full Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_fullStr Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_full_unstemmed Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
title_sort differential regulation of oct4 targets facilitates reacquisition of pluripotency
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Barriers underlying the inefficiency of reprogramming cells to pluripotency are poorly defined. Here the authors identify a transient interval soon after pluripotency exit that permits high-efficiency reprogramming and is facilitated by OCT4 bound elements displaying unique silencing behaviour during differentiation.
url https://doi.org/10.1038/s41467-019-11741-5
work_keys_str_mv AT sudhirthakurela differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT camillesindhu differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT evgenyyurkovsky differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT christinariemenschneider differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT zacharydsmith differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT iftachnachman differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
AT alexandermeissner differentialregulationofoct4targetsfacilitatesreacquisitionofpluripotency
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