NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)

NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC)

Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including ac...

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Bibliographic Details
Main Authors: Luciana O. Almeida, Aline C. Abrahao, Luciana K. Rosselli-Murai, Fernanda S. Giudice, Chiara Zagni, Andreia M. Leopoldino, Cristiane H. Squarize, Rogerio M. Castilho
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
HNSCC
Chromatin remodeling
HDAC inhibitor
Histone acetylation
NFκB
Chemoresistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546313000776

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http://www.sciencedirect.com/science/article/pii/S2211546313000776

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