Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface and disrupts the normal recycling of the LDLR. In this study, we investigated the role of the C-terminal domain for the activity of PCSK9. Experiments in which conserved res...

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Bibliographic Details
Main Authors: Øystein L. Holla, Jamie Cameron, Kristian Tveten, Thea Bismo Str⊘m, Knut Erik Berge, Jon K. Laerdahl, Trond P. Leren
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Journal of Lipid Research
Subjects:
proprotein convertase subtilisin/kexin type 9
endosomes
recycling
sorting
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408430

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http://www.sciencedirect.com/science/article/pii/S0022227520408430

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