Distinct Requirements of CHD4 during B Cell Development and Antibody Response

Distinct Requirements of CHD4 during B Cell Development and Antibody Response

Summary: The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remodeling NuRD complex, directly binds H3K9me3, an epi...

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Main Authors: Wei-Feng Yen, Rahul Sharma, Montserrat Cols, Colleen M. Lau, Ashutosh Chaudhry, Priyanka Chowdhury, William T. Yewdell, Bharat Vaidyanathan, Amy Sun, Maryaline Coffre, Joseph N. Pucella, Chun-Chin Chen, Maria Jasin, Joseph C. Sun, Alexander Y. Rudensky, Sergei B. Koralov, Jayanta Chaudhuri
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719304668

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http://www.sciencedirect.com/science/article/pii/S2211124719304668

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