Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors

Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors

Recent reports have documented the differentiation of human pluripotent stem cells toward the skeletal myogenic lineage using transgene- and cell purification-free approaches. Although these protocols generate myocytes, they have not demonstrated scalability, safety, and in vivo engraftment, which a...

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Bibliographic Details
Main Authors: Jaemin Kim, Alessandro Magli, Sunny S.K. Chan, Vanessa K.P. Oliveira, Jianbo Wu, Radbod Darabi, Michael Kyba, Rita C.R. Perlingeiro
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
pluripotent stem cells
skeletal muscle
morphogens
purification
PAX7+ myogenic progenitors
MHC+ myocytes
transgene
engraftment
stem cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301765

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http://www.sciencedirect.com/science/article/pii/S2213671117301765

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