White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.

INTRODUCTION:White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of ce...

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Main Authors: Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman, Dominantly Inherited Alzheimer Network
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5942789?pdf=render

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http://europepmc.org/articles/PMC5942789?pdf=render

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