Study of the L-Phenylalanine Ammonia-Lyase Penetration Kinetics and the Efficacy of Phenylalanine Catabolism Correction Using In Vitro Model Systems

Study of the L-Phenylalanine Ammonia-Lyase Penetration Kinetics and the Efficacy of Phenylalanine Catabolism Correction Using In Vitro Model Systems

The kinetics of L-phenylalanine ammonia-lyase (PAL) penetration into the monolayer of liver cells after its release from capsules was studied. The studies showed the absence of the effect of the capsule shell based on plant hydrocolloids on the absorption of L-phenylalanine ammonia-lyase in systems...

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Bibliographic Details
Main Authors: Lyubov Dyshlyuk, Stanislav Sukhikh, Svetlana Noskova, Svetlana Ivanova, Alexander Prosekov, Olga Babich
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
phenylketonuria
L-phenylalanine ammonia-lyase
enzyme
kinetics
catabolism disorder
biomedical drug
Online Access:https://www.mdpi.com/1999-4923/13/3/383

Internet

https://www.mdpi.com/1999-4923/13/3/383

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