Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.

Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.

Human induced pluripotent stem cells (hiPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, iPSC-derived grafts are at risk of giving rise to teratomas in the host, if residuals of tumorigenic cells are not rejected...

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Bibliographic Details
Main Authors: Vanessa Kruse, Carina Hamann, Sebastian Monecke, Lukas Cyganek, Leslie Elsner, Daniela Hübscher, Lutz Walter, Katrin Streckfuss-Bömeke, Kaomei Guan, Ralf Dressel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4423859?pdf=render

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http://europepmc.org/articles/PMC4423859?pdf=render

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