A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

NRF2 is a master regulator of cellular anti-oxidant and anti-inflammatory responses, and strategies to augment NRF2-dependent responses may beneficial in many diseases. Basal NRF2 protein level is constrained by constitutive KEAP1-mediated degradation, but in the presence of electrophiles, NRF2 ubiq...

Full description

Bibliographic Details
Main Authors: Yanwen Chen, John W. Evankovich, Travis B. Lear, Ferhan Tuncer, Jason R. Kennerdell, Daniel P. Camarco, Morgan S. Shishido, Yuan Liu, Bill B. Chen
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
NRF2
DCAF1
High throughput screening
Drug discovery
Ubiquitination
E3 ligase
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302962

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720302962

Similar Items