Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Extensive molecular profiling of leukemias and preleukemic diseases has revealed that distinct clinical entities, like acute myeloid (AML) and T-lymphoblastic leukemia (T-ALL), share similar pathogenetic mutations. It is not well understood how the cell of origin, accompanying mutations, extracellul...

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Bibliographic Details
Main Authors: Courteney K Lai, Yeonsook Moon, Florian Kuchenbauer, Daniel T Starzcynowski, Bob Argiropoulos, Eric Yung, Philip Beer, Adrian Schwarzer, Amit Sharma, Gyeongsin Park, Malina Leung, Grace Lin, Sarah Vollett, Stephen Fung, Connie J Eaves, Aly Karsan, Andrew P Weng, R Keith Humphries, Michael Heuser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4234417?pdf=render

Internet

http://europepmc.org/articles/PMC4234417?pdf=render

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