Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.

Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.

There is no effective vaccine against Buruli ulcer. In experimental footpad infection of C57BL/6 mice with M. ulcerans, a prime-boost vaccination protocol using plasmid DNA encoding mycolyltransferase Ag85A of M. ulcerans and a homologous protein boost has shown significant, albeit transient protect...

Full description

Bibliographic Details
Main Authors: Virginie Roupie, Sacha J Pidot, Tobba Einarsdottir, Christophe Van Den Poel, Fabienne Jurion, Timothy P Stinear, Kris Huygen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3879250?pdf=render

Internet

http://europepmc.org/articles/PMC3879250?pdf=render

Similar Items