Preclinical development of an in vivo BCG challenge model for testing candidate TB vaccine efficacy.

There is an urgent need for an immunological correlate of protection against tuberculosis (TB) with which to evaluate candidate TB vaccines in clinical trials. Development of a human challenge model of Mycobacterium tuberculosis (M.tb) could facilitate the detection of such correlate(s). Here we pro...

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Bibliographic Details
Main Authors: Angela M Minassian, Edward O Ronan, Hazel Poyntz, Adrian V S Hill, Helen McShane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3101220?pdf=render