Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and...

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Main Authors:	Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G. Mirmira, Nahum Sonenberg, Ming Liu, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms16014

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spelling	doaj-effc74d97aa34c3f83d6c968e34437032021-05-11T07:12:37ZengNature Publishing GroupNature Communications2041-17232017-07-018111510.1038/ncomms16014Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processingManuel Blandino-Rosano0Rebecca Barbaresso1Margarita Jimenez-Palomares2Nadejda Bozadjieva3Joao Pedro Werneck-de-Castro4Masayuki Hatanaka5Raghavendra G. Mirmira6Nahum Sonenberg7Ming Liu8Markus A. Rüegg9Michael N. Hall10Ernesto Bernal-Mizrachi11Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of MedicineDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical CenterDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical CenterDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical CenterDivision of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of MedicineDepartment of Pediatrics, Indiana University School of MedicineDepartment of Pediatrics, Indiana University School of MedicineDepartment of Biochemistry, McGill UniversityDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan Medical CenterBiozentrum, University of BaselBiozentrum, University of BaselDivision of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of MedicineDeregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.https://doi.org/10.1038/ncomms16014
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi
spellingShingle	Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing Nature Communications
author_facet	Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi
author_sort	Manuel Blandino-Rosano
title	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_short	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_full	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_fullStr	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_full_unstemmed	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_sort	loss of mtorc1 signalling impairs β-cell homeostasis and insulin processing
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.
url	https://doi.org/10.1038/ncomms16014
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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

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