The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?

by Perrine Castets, Daniel J. Ham, Markus A. Rüegg
Published 2020-08-01

Fatigue and muscle atrophy in a mouse model of myasthenia gravis is paralleled by loss of sarcolemmal nNOS.

by Sarina Meinen, Shuo Lin, Markus A Rüegg, Anna Rostedt Punga
Published 2012-01-01

mTORC2 affects the maintenance of the muscle stem cell pool

by Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg
Published 2019-12-01

The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory

by Judith R. Reinhard, Alexander Kriz, Milos Galic, Nico Angliker, Mathieu Rajalu, Kaspar E. Vogt, Markus A. Ruegg
Published 2016-05-01

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

by Xiaolei Ding, Wilhelm Bloch, Sandra Iden, Markus A. Rüegg, Michael N. Hall, Maria Leptin, Linda Partridge, Sabine A. Eming
Published 2016-10-01

mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

by Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
Published 2020-02-01

Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.

by Stefan Hettwer, Shuo Lin, Stefan Kucsera, Monika Haubitz, Filippo Oliveri, Ruggero G Fariello, Markus A Ruegg, Jan W Vrijbloed
Published 2014-01-01

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

by Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Published 2021-02-01

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

by Marina Boido, Elena De Amicis, Valeria Valsecchi, Marco Trevisan, Ugo Ala, Markus A. Ruegg, Stefan Hettwer, Alessandro Vercelli, Alessandro Vercelli
Published 2018-01-01

WNT7B promotes bone formation in part through mTORC1.

by Jianquan Chen, Xiaolin Tu, Emel Esen, Kyu Sang Joeng, Congxin Lin, Jeffrey M Arbeit, Markus A Rüegg, Michael N Hall, Liang Ma, Fanxin Long
Published 2014-01-01

Neuropathology in mice expressing mouse alpha-synuclein.

by Claus Rieker, Kumlesh K Dev, Katja Lehnhoff, Samuel Barbieri, Iwona Ksiazek, Sabine Kauffmann, Simone Danner, Heinrich Schell, Cindy Boden, Markus A Ruegg, Philipp J Kahle, Herman van der Putten, Derya R Shimshek
Published 2011-01-01

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

by Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G. Mirmira, Nahum Sonenberg, Ming Liu, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Published 2017-07-01

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

by Lianjun Zhang, Benjamin O. Tschumi, Isabel C. Lopez-Mejia, Susanne G. Oberle, Marten Meyer, Guerric Samson, Markus A. Rüegg, Michael N. Hall, Lluis Fajas, Dietmar Zehn, Jean-Pierre Mach, Alena Donda, Pedro Romero
Published 2016-02-01

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4

by Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guérard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Rüdiger Rudolf, David J. Glass, Markus A. Rüegg
Published 2019-07-01

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

by Camilla Norrmén, Gianluca Figlia, Frédéric Lebrun-Julien, Jorge A. Pereira, Martin Trötzmüller, Harald C. Köfeler, Ville Rantanen, Carsten Wessig, Anne-Lieke F. van Deijk, August B. Smit, Mark H.G. Verheijen, Markus A. Rüegg, Michael N. Hall, Ueli Suter
Published 2014-10-01

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

by Maximilian Kleinert, Benjamin L. Parker, Rima Chaudhuri, Daniel J. Fazakerley, Annette Serup, Kristen C. Thomas, James R. Krycer, Lykke Sylow, Andreas M. Fritzen, Nolan J. Hoffman, Jacob Jeppesen, Peter Schjerling, Markus A. Ruegg, Bente Kiens, David E. James, Erik A. Richter
Published 2016-08-01

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

by Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Published 2020-09-01