Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload

Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload

Background: Volume overload (VO) of isolated mitral regurgitation (MR) or aortocaval fistula (ACF) is associated with extracellular matrix degradation and cardiomyocyte myofibrillar and desmin breakdown. Left ventricular (LV) chymase activity is increased in VO and recent studies demonstrate chymase...

Full description

Bibliographic Details
Main Authors: Pamela C. Powell, Chih-Chang Wei, Lianwu Fu, Betty Pat, Wayne E. Bradley, James F. Collawn, Louis J. Dell'Italia
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Heliyon
Subjects:
Cardiology
Cell biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018366258

Internet

http://www.sciencedirect.com/science/article/pii/S2405844018366258

Similar Items