Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

Huntington disease (HD), caused by expansion >35 of a polyglutamine tract in huntingtin, results in degeneration of striatal medium spiny neurons (MSNs). Previous studies demonstrated mitochondrial dysfunction, altered intracellular calcium release, and enhanced NMDAR-mediated current and apoptos...

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Bibliographic Details
Main Authors: Jacqueline Shehadeh, Herman B. Fernandes, Melinda M. Zeron Mullins, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden, Lynn A. Raymond
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Subjects:
Apoptosis
Mitochondria
Primary neuronal culture
Excitotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002172

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http://www.sciencedirect.com/science/article/pii/S0969996105002172

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