Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
Huntington disease (HD), caused by expansion >35 of a polyglutamine tract in huntingtin, results in degeneration of striatal medium spiny neurons (MSNs). Previous studies demonstrated mitochondrial dysfunction, altered intracellular calcium release, and enhanced NMDAR-mediated current and apoptos...
Main Authors: | Jacqueline Shehadeh, Herman B. Fernandes, Melinda M. Zeron Mullins, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden, Lynn A. Raymond |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-02-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996105002172 |
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