Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implications for infection control

Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implications for infection control

We used quantal dose-titration of a mouse-adapted human transmissible spongiform encephalopathy strain (M470) to compare different analytical methods for their ability to detect asymptomatic brain prion infection after low dose inoculation. At a time point approximately 2.5-fold beyond the mean incu...

Full description

Bibliographic Details
Main Authors: Steven J. Collins, Victoria Lewis, Marcus W Brazier, Andrew F. Hill, Victoria A. Lawson, Genevieve M. Klug, Colin L. Masters
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Prions
Creutzfeldt–Jakob disease
Asymptomatic infection
Preclinical infection
Subclinical infection
Transmissible spongiform encephalopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000902

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105000902

Similar Items