Allosteric Antagonism of the A<sub>2A</sub> Adenosine Receptor by a Series of Bitopic Ligands
Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR) ligand classes were reported as pharmacological tools, their receptor binding and functi...
Main Authors: | Zhan-Guo Gao, Kiran S. Toti, Ryan Campbell, R. Rama Suresh, Huijun Yang, Kenneth A. Jacobson |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-05-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/5/1200 |
Similar Items
-
Functional Expression of Adenosine A<sub>3</sub> Receptor in Yeast Utilizing a Chimera with the A<sub>2A</sub>R C-Terminus
by: Abhinav Jain, et al.
Published: (2020-06-01) -
A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic?
by: Fabrizio Vincenzi, et al.
Published: (2020-12-01) -
An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts
by: Roselyn B. Rose'Meyer, et al.
Published: (2013-04-01) -
Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor
by: Pramisha Adhikari, et al.
Published: (2021-04-01) -
Functional Consequences of GPCR Heterodimerization: GPCRs as Allosteric Modulators
by: Karla K.V. Haack, et al.
Published: (2011-03-01)