The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.

The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor for GBS, which is generally attributed to its cytolytic functions. Here we show βh/c...

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Bibliographic Details
Main Authors: Magali Bebien, Mary E Hensler, Suzel Davanture, Li-Chung Hsu, Michael Karin, Jin Mo Park, Lena Alexopoulou, George Y Liu, Victor Nizet, Toby Lawrence
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3400567?pdf=render

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http://europepmc.org/articles/PMC3400567?pdf=render

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