Improvement of the trivalent inactivated flu vaccine using PapMV nanoparticles.

Commercial seasonal flu vaccines induce production of antibodies directed mostly towards hemaglutinin (HA). Because HA changes rapidly in the circulating virus, the protection remains partial. Several conserved viral proteins, e.g., nucleocapsid (NP) and matrix proteins (M1), are present in the vacc...

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Bibliographic Details
Main Authors: Christian Savard, Annie Guérin, Karine Drouin, Marilène Bolduc, Marie-Eve Laliberté-Gagné, Marie-Christine Dumas, Nathalie Majeau, Denis Leclerc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3126827?pdf=render