The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition

The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition

Objective: MicroRNAs (miRNA) are known to regulate the expression of genes involved in several physiological processes including metabolism, mitochondrial biogenesis, proliferation, differentiation, and cell death. Methods: Using “in silico” analyses, we identified 219 unique miRNAs that potentially...

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Bibliographic Details
Main Authors: André L. Queiroz, Sarah J. Lessard, Amanda T. Ouchida, Hygor N. Araujo, Dawit A. Gonçalves, Dimitrius Santiago P. Simões Fróes Guimarães, Bruno G. Teodoro, Kawai So, Enilza M. Espreafico, Michael F. Hirshman, Luciane C. Alberici, Isis do Carmo Kettelhut, Laurie J. Goodyear, Leonardo R. Silveira
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Metabolism
Subjects:
miR-696
Mitochondrial function
Skeletal muscle
SNARK
Pgc1α
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000715

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http://www.sciencedirect.com/science/article/pii/S2212877821000715

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