Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it potentiates excitotoxic signaling. The key GluN2B CTD...

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Bibliographic Details
Main Authors: Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
NMDA receptor
excitotoxicity
neurodegeneration
calcium signaling
Online Access:https://elifesciences.org/articles/17161

Internet

https://elifesciences.org/articles/17161

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