Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

Apoptotic resistance remains a hallmark of glioblastoma (GBM), the most common primary brain tumor in adults, and a better understanding of this process may result in more efficient treatments. By utilizing chromatin immunoprecipitation with next-generation sequencing (CHIP-seq), we discovered that...

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Bibliographic Details
Main Authors: Enyuan Shang, Trang T. T. Nguyen, Chang Shu, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
THZ1
BH3-mimetics
Mcl1
super-enhancer
non-coding regions
epigenome
Online Access:https://www.mdpi.com/2072-6694/12/8/2137

Internet

https://www.mdpi.com/2072-6694/12/8/2137

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