Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be...

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Bibliographic Details
Main Authors: Efthymia Vokali, Shann S. Yu, Sachiko Hirosue, Marcela Rinçon-Restrepo, Fernanda V. Duraes, Stefanie Scherer, Patricia Corthésy-Henrioud, Witold W. Kilarski, Anna Mondino, Dietmar Zehn, Stéphanie Hugues, Melody A. Swartz
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14127-9

Internet

https://doi.org/10.1038/s41467-019-14127-9

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