Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2

Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2

Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports the role of reactive astrocytes as mediators of changes in neurons, including synapses. However, the complexity a...

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Bibliographic Details
Main Authors: Erica Staurenghi, Valentina Cerrato, Paola Gamba, Gabriella Testa, Serena Giannelli, Valerio Leoni, Claudio Caccia, Annalisa Buffo, Wendy Noble, Beatriz Gomez Perez-Nievas, Gabriella Leonarduzzi
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Redox Biology
Subjects:
Oxysterols
Astrocytes
Astrocyte reactivity
Lipocalin-2
Synaptotoxicity
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310429

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http://www.sciencedirect.com/science/article/pii/S2213231720310429

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