An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins involved in CM pathogenesis and whose inhibition may be of therapeutic value. One pedigree (P48) segregated a resistance trait whose CM-protective...

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Bibliographic Details
Main Authors: Silayuv E Bongfen, Ian-Gael Rodrigue-Gervais, Joanne Berghout, Sabrina Torre, Pablo Cingolani, Sean A Wiltshire, Gabriel A Leiva-Torres, Louis Letourneau, Robert Sladek, Mathieu Blanchette, Mark Lathrop, Marcel A Behr, Samantha Gruenheid, Silvia M Vidal, Maya Saleh, Philippe Gros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363534/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363534/pdf/?tool=EBI

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