Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).

Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).

CEL-MODY is a monogenic form of diabetes with exocrine pancreatic insufficiency caused by mutations in CARBOXYL-ESTER LIPASE (CEL). The pathogenic processes underlying CEL-MODY are poorly understood, and the global knockout mouse model of the CEL gene (CELKO) did not recapitulate the disease. We the...

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Main Authors: Helge Ræder, Mette Vesterhus, Abdelfattah El Ouaamari, Joao A Paulo, Fiona E McAllister, Chong Wee Liew, Jiang Hu, Dan Kawamori, Anders Molven, Steven P Gygi, Pål R Njølstad, C Ronald Kahn, Rohit N Kulkarni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3615023?pdf=render

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http://europepmc.org/articles/PMC3615023?pdf=render

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