2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.

2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.

BACKGROUND: There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-...

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Bibliographic Details
Main Authors: Luke Mercer, Tana Bowling, Joe Perales, Jennifer Freeman, Tien Nguyen, Cyrus Bacchi, Nigel Yarlett, Robert Don, Robert Jacobs, Bakela Nare
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3035674?pdf=render

Internet

http://europepmc.org/articles/PMC3035674?pdf=render

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