Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

Abstract Background The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymogens that activate at low pH by autocatalytic removal of their N-termi...

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Bibliographic Details
Main Authors: Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton, Carolina De M. Verissimo
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Molecular and Cell Biology
Subjects:
Cathepsin L
Cysteine peptidases
Propeptide
Inhibitor
Fasciola hepatica
Online Access:https://doi.org/10.1186/s12860-020-00335-5

Internet

https://doi.org/10.1186/s12860-020-00335-5

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